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                    國家首批“2011計劃”大學 | 探索“全程導師制,全員書院制”人才培養模式
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                    何冰芳
                       閱讀次數: 添加時間:2017/09/30 發布者:教學管理  

                    何冰芳,教授bbin体育官网平台,博士生導師bbin体育官网平台,1962年11月生。

                    1978.10-1982.7中國藥科大學(原“南京藥學院”)藥物化學(學士)。

                    1982.7-1987.10中國藥科大學生物化學教研室助教、講師。

                    1984.9-1987.6中國藥科大學,生物藥物學(碩士)。

                    1987.10-1995.3日本筑波大學(University of Tsukuba, Japan)化學系,醫學系外國人研究員。

                    1995.4-1997.11中國藥科大學生物制藥學院講師、副教授bbin体育官网平台。

                    1997.11-2001.3日本筑波大學(University of Tsukuba)應用生化系微生物(博士)。

                    2001.9-2013.4南京工業大學制藥與生命科學學院(09年~副院長)教授、2003年博士生導師。

                    2013.4-至今bbin体育官网平台,南京工業大學藥學院黨委書記、教授bbin体育官网平台、博士生導師

                    江蘇省“六大人才高峰”和江蘇省“青藍工程”中青年學術帶頭人bbin体育官网平台。2006年榮獲南京工業大學“教學名師”、2006、2008年兩次獲得“十佳師德標兵”稱號;2007獲江蘇省人民政府教學成果特等獎;2008年榮獲“江蘇省高等學校優秀共產黨員”bbin体育官网平台;2009年獲國家教學成果二等獎;2011年獲得江蘇省“大學生最喜愛的教師”稱號;2013年榮獲“江蘇省教育科技系統五一巾幗標兵”稱號。

                    學術兼職:
                       全國微生物學會理事
                       全國生物化學與分子生物技術學會理事
                       江蘇省生物化學與分子生物學學會常務理事

                    江蘇省微生物學會副理事長

                    培養學生:指導學生多次獲得江蘇省優秀論文:江蘇省優秀博士論文(許家興2014);江蘇省優秀碩士論文獎2次(唐嘯宇2010,孫洪林2012)bbin体育官网平台;江蘇省本科優秀畢業設計獎一等獎1次(王麗娟2008)bbin体育官网平台,江蘇省本科優秀畢業設計獎二等獎3次(謝承佳2004,何小丹2006,吳珊珊2012)bbin体育官网平台;

                    研究方向:
                       研究方向為微生物學與生化制藥、分子生物學bbin体育官网平台、酶工程。主要從事生化制藥,包括微生物菌種篩選, 非水相生物催化, 酶催化機理與調控, 生物制藥高效酶類的設計與制備,高效生化藥物合成等研究,;特別是極端微生物新功能及其新酶類的發現與開發,尤其是耐有機溶媒極端微生物及其工業用生物催化劑等發現與功能開發bbin体育官网平台,并將其用于醫藥中間體的拆分與制備,活性小肽的制備,中草藥有效成分改造bbin体育官网平台。已發表論文100余篇, SCI論文50余篇,申請國家發明專利30余項bbin体育官网平台,已獲授權國家發明專利28項,國際發明專利2項bbin体育官网平台。 
                       主持完成863計劃(新型耐有機溶劑蛋白酶的高通量篩選與改造技術),國家自然科學基金(基于大腸桿菌胞外分泌表達能力的調控元件研究)bbin体育官网平台,國家博士點專項基金一項(生物偶聯制氫技術的研究)bbin体育官网平台,江蘇省高校自然科學研究重大項目(黃酮類化合物非水相高效糖基化生物改性體系的研究)bbin体育官网平台,江蘇省自然科學基金2項(新型手性羥基酸合成酶的性質研究,耐有機溶劑甾體羥化工程菌的構建與其雙相甾體催化)bbin体育官网平台,江蘇高校高新技術項目 (一菌雙酶偶聯法生產 L-苯丙氨酸),并參與完成973項目及863重點項目各2項bbin体育官网平台。
                       目前主持國家自然科學基金(基于重要糖苷天然產物合成的酶分子改造研究),博士點基金(優先發展領域)項目(基于高效催化紅景天苷合成的糖苷酶解析及其底物識別機制研究),并參與973項目1項。
                    發表的部分論文(*通訊作者):
                        1. He B.F., Nakajima-Kambe,T., Ozawa,T., Nakahara,T.:  Production of D-malate and D-citramalate by Arthrobacter pascens DMDC12 having stable citraconase.  Process Biochemistry 2000, 36: 407-414  ( SCI 1.07)
                        2. He B.F., Ozawa,T., Nakajima-Kambe,T., Nakahara,T.:  Efficient conversion of itaconic acid to (S)-(+)-citramalic acid by Alcaligenes xylosoxydans IL142.  Journal of Bioscience and Bioengineering 2000, 89: 388- 391 ( SCI 1.136)
                        3. Shoda,J., He B.F., Tanaka,N., Matsuzaki,Y., Shyunji,Y., Osuga,T.: Primary dual defect of cholesterol and bile acid metabolism in liver of patients with intrahepatic calculi. Gastroenterology 1995, 108: 1534-1546, ( SCI 12.457)
                        4. Shoda,J., He B.F., Tanaka, N., Matsuzaki,Y., Osuga,T., Yamamori,S., Miyazaki,H., Sjovall,J.: Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease, and its correlation with de novo synthese of cholesterol and bile acid in liver, gallbladder emptying, and small intestinal transit.  Hepatology 1995, 21: 1291-1302 ( SCI 10.446)
                        5. X.Y. Tang, Y. Pan, S. Li, B.F. He*  Screening and isolation of an organic solvent-tolerant bacterium high-yield producing a novel organic solvent-stable protease.  Bioresource technology 2008, 99: 7388-7392  (IF 4.452)
                        6. Yanzhen Mei, Bingfang He*, Pingkai Ouyang. Enzymatic Production of L-Amino Acids from the Corresponding DL-5-Substituted Hydantoins by Bacillus fordii MH602.  World J. of Microbiol. & Biotechnol. 2008 24:375-381. (IF 0.945)
                        7. Shuang. Li, Bingfang He*, Zhongzhong Bai, Pingkai Ouyang; A novel organic-solvent-stable alkaline protease from organic-solvent-tolerant Bacillus licheniformis YP1A.  Journal of molecular catalysis b-enzymatic  2009, 56: 85-88. (IF 2.015)
                        8. Yan Li , Xian Xu, Matthias Dietrich, Vlada B. Urlacher, Rolf D. Schmid, Pingkai Ouyang, Bingfang He*,Identification and functional expression of △9 fatty acid desaturase from the marine bacterium Pseudoalteromonas sp. MLY15.  Journal of molecular catalysis b-enzymatic  2009, 56:96-101.  (IF 2.015)
                        9. Yanzhen Mei, Bingfang He*, Nina Liu, Pingkai Ouyang. Screening and Distributing Features of Bacteria with Hydantoinase and Carbamoylase.  Microbiological Research  2009, 164: 322-329  (IF 2.054)
                        10. Yanzhen Mei, Yongmin Wan,Bingfang He *;Hanjie Ying,Pingkai Ouyang; New gene cluster from thermophile Bacillus fordii MH602 for conversion of DL-5-substituted hydantoins to L-amino acids.  J. Microbiol. Biotechnol. 2009, 19(12), 1497-1505 (IF 2.062)
                        11. TingTing Xu, ZhongZhong Bai, LiJuan Wang, BingFang He*; Breeding of D(-)-lactic Acid High Producing Strain by Low-energy Ion Implantation and Preliminary Analysis of Related Metabolism.  Appl. biochem. and biotechnol. 2010, 160: 314-321, (IF 1.04)
                        12. XiaoYu Tang . Bin Wu . HanJie Ying . BingFang He*; Biochemical properties and potential applications of a solvent-stable protease from the high-yield protease producer Pseudomonas aeruginosa PT121.  Appl. biochem. and biotechnol. 2010, 160: 1017-1031, (IF 1.04)
                        13. MaoHua Wan, Bin Wu, Wei Ren, BingFang He*;Screening, characterization, and cloning of a solvent-tolerant protease from Serratia marcescens MH6.  J. Microbiol. Biotechnol. 2010, 20(5), 881-888 (IF 2.062)
                        14. Jiaxing Xu, Min Jiang, Honglin Sun, Bingfang He*; An Organic Solvent-Stable Protease from Organic Solvent-Tolerant Bacillus cereus WQ9-2: Purification, Biochemical Properties, and Potential Application in Peptide Synthesis.  Bioresource technology 2010, 901: 7991-7994  (IF 4.253)
                        15. Qingchun Ji, Sujing Xiao, Bingfang He*, Xiaoning Liu; Purification and characterization of an organic solvent-tolerant lipase from Pseudomonas aeruginosa LX1 and its application for biodiesel production.  J. Molecular Catalysis B: Enzymatic 2010 66: 264-269  (IF 2.400)

                    16. Bin Wu, Zhongzhong Bai, Xiao Meng, Bingfang He*; Efficient Production of D-glucosaminate from Dglucosamine by Pseudomonas putida GNA5.  Biotechnology Progress 2011, 27 (1): 32-37  (IF 2.398)
                    17. Honglin Sun, Bingfang He*, Jiaxing Xu, Bin Wu, Pingkai Ouyang; Efficient chemo-enzymatic synthesis of endomorphin-1 using organic solvent stable proteases.  Green Chemistry 2011,13,1680-1685  (IF 5.836)  

                    18. Yan Cao, Yu Zhuang, Changjin Yao, Bin Wu, Bingfang He*; Purification and characterization of an organic solvent-stable lipase from Pseudomonas stutzeri LC2-8 and its application for efficient resolution of (R, S)-1-phenylethanol. Biochemical Engineering Journal 2012, 64(15), 55–60  (IF 2.645)   

                    19. Lu Zheng, Zhong-zhong Bai, Ting-ting Xu, Bing-fang He*; Glucokinase contributes to glucose phosphorylation in D-lactic acid production by Sporolactobacillus inulinus Y2-8  J Ind Microbiol Biotechnol 2012, 39:1685–1692 (IF 2.735)

                    20. Chenghua Wang, Ribo Huang, Bingfang He, Qishi Du*,Improving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis BMC Bioinformatics 2012, 13:263

                    21. Changjin Yao; Yan Cao; Shanshan Wu; Shuang Li; Bingfang He*, An organic solvent and thermally stable lipase from Burkholderia ambifaria YCJ01: purification, characteristics and application for chiral resolution of mandelic acid J. Molecular Catalysis B: Enzymatic 2013, 85-86, 105-110  (IF 2.735)  

                    22. Jiaxing Xu,Yu Zhuang,Bin Wu,Long Su,Bingfang He* Calcium ion-Induced Stabilization of the Protease from Bacillus cereus WQ9-2 in Aqueous Hydrophilic Solvents: Effect of Calcium Ion Binding on the Hydration Shell and Intramolecular Interactions J. Biological Inorganic Chemistry 2013, 18:211-221 (IF 3.289)

                    23. Jiaxing Xu, Honglin Sun, Xuejun He, Zhongzhong Bai, Bingfang He*,Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal  Bioresource technology 2013 (129) 663–666  (IF 4.98)

                    24. Sen Zhang, Zhi Zhou, Zhong Yao, Bingfang He*; Efficient production of skimmin and 6'-succinylskimmin from umbelliferone by organic solvent-tolerant Bacillus licheniformis ZSP01 using nitrogen sources regulation strategy. Biochemical Engineering Journal 2013 (71) 105–110 (IF 2.645)

                    25. Xueming Wu, Jianlin Chu, Bin Wu,Sen Zhang,Bingfang He*;An Efficient Novel Glycosylation of Flavonoid by β-Fructosidase Resistant to Hydrophilic Organic Solvents. Bioresource technology 2013 (129) 659–662  (IF 4.98)

                    26. Xueming Wu, Jianlin Chu, Jingyu Liang and Bingfang He*;Efficient enzymatic synthesis of mangiferin glycosides in hydrophilic organic solvents. RSC Advances  (Royal Society of Chemistry Advances) 2013, 3, 19027–19032 (IF 2.562)

                    27. Xueming Wu, Jianlin Chu, Tingting Xu, Bingfang He;Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation.  J of chromatography B, 2013; 935C:70-74. (IF2.78) 

                    28. Lu Zheng, Tingting Xu, Zhongzhong Bai, Bingfang He*; Mn2+/Mg2+-dependent pyruvate kinase from a D-lactic acid-producing bacterium Sporolactobacillus inulinus: characterization of a novel Mn2+-mediated allosterically regulated enzyme Applied Microbiology and Biotechnology  2014,98(4): 1583-1593 (IF 3.811)

                    29. Jiaxing Xu, Zhi Zhou, Bin Wu, Long Su, Bingfang He* Enzymatic formation of a novel cell-adhesive hydrogel based on small peptides with laterally grafted L-3, 4-dihydroxyphenylalanine group,  Nanoscale, 2014, 6, 1277–1280 (IF6.739)

                    30. Jianlin Chu, Xueming Wubbin体育官网平台,Bo Li,Bingfang He*; Ef?cient Glucosylation of Flavonoids by Organic Solvent-Tolerant Staphylococcus saprophyticus CQ16 in Aqueous Hydrophilic Media, J. Molecular Catalysis B: Enzymatic  2014, 99: 8-13 (IF 2.745) 

                    31. Yan Cao, Shanshan Wu, Jiahuang Li, Bin Wu, Bingfang He*; Highly efficient resolution of mandelic acid using lipase from Pseudomonas stutzeri LC2-8 and a molecular modeling approach to rationalize its enantioselectivity  J. Molecular Catalysis B: Enzymatic 2014, 99:108-113 (IF 2.745)

                    32. Jiaxing Xu, Bingfang He, Bin Wu, Bin Wang, Chenghua Wang, Lei Hu; An ionic liquid tolerant cellulase derived from chemically polluted microhabitats and its application in in situ saccharification of rice straw  Bioresource Technology  2014, 157(1): 166–173. (IF: 5.039).

                    33. Bin Wang, Wenhao Li, Bin Wu, Bingfang He*; Ef?cient resolution of 3-phenoxy-1,2-propanediol by immobilized lipase on amphiphilic comb polymer modi?ed TiO2. J. Molecular Catalysis B: Enzymatic 2014, 106: 105–110 (IF 2.745) 

                    34. Jianlin Chu, Xueming Wu, Bin Wu, Rui Wang, Bingfang He*; Characteristics of an organic solvent-tolerant β-fructofuranosidase from Arthrobacter arilaitensis NJEM01 with board substrate specificity and efficiently biosynthesize prebiotic kestose. J. Agricultural & Food Chemistry 2014 62(4): 5408-5411 (IF 3.107) 

                    35. Chenghua Wang, Qingyan Wang, Siming Liao, Bingfang He, Ribo Huang*; Thermal stability and activity improvements of a Ca-independentα-amylase fromBacillus subtilisCN7 by C-terminal truncation and hexahistidine-tag fusion。 Biotechnology and Applied Biochemistry 2014,2,99-100 (IF 1.322)

                    36. Keke Liu, Fucheng Zhu, Ling Zhu, Guoguang Chen, Bingfang He*; Highly  efficient  enzymatic  synthesis  of  Z-aspartame  in  aqueous medium  via  in  situ  product  removal. Biochemical Engineering Journal  98 (2015) 63–67

                    37. Sen Zhang, Guoguang Chen, Jianlin Chu, Bin Wu, Bingfang He*; High production of succinyl isoflavone glycosides by Bacillus licheniformis ZSP01 resting cells in aqueous miscible organic medium. Biotechnology and Applied Biochemistry  DOI: 10.1002/bab.1258

                    38. Jiaduo Sun, Lu Zheng, Bin Wu, Bingfang He*; Enhanced production rate of D-lactic acid by Sporolactobacillus sp.Y2-8 mutant generated by atmospheric and room temperature plasma. Biotechnology and Applied Biochemistry   DOI: 10.1002/bab.1267
                       注:“*”為corresponding author  Email: bingfanghe@njtech.edu.cn


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